San Francisco 49ers

San Francisco 49ers wide receiver Brandon Aiyuk (knee) had surgery on his right knee earlier this week to fix a torn ACL and other damage. In addition to tearing his ACL, Aiyuk also tore his MCL in the Week 7 loss to the Kansas City Chiefs and will miss the rest of the season. He should have already been dropped in single-season fantasy leagues. It remains to be seen if the 26-year-old will make enough progress in his rehab in the offseason in order to be ready to play in Week 1 of the 2025 regular season next fall. For the rest of 2024, receivers Deebo Samuel Sr. and Jauan Jennings and tight end George Kittle should be the most-targeted pass-catchers, with rookie first-rounder Ricky Pearsall also seeing an expanded role in the passing attack. Aiyuk was an absolute fantasy bust this year, finishing with 25 catches for 374 yards and no touchdowns in seven games.

San Francisco 49ers wide receiver Jauan Jennings (ankle) was removed from Friday's final Week 11 injury report and will be available to play on Sunday when the team takes on the division-rival Seattle Seahawks at Levis Stadium. Jennings popped up on the injury report on Thursday after being limited in practice, putting his availability for Sunday's game in question. The 27-year-old is now in the clear, though, and could have another big role in San Fran's passing attack against Seattle after leading the team in targets (11) and receiving yards (93) in the Week 10 victory over the Tampa Bay Buccaneers. Jennings had missed the two previous games due to a hip injury. With Brandon Aiyuk (knee) done for the year, Jennings' elevated role should be secure the rest of the year. The Seahawks D has allowed the second-most half-PPR points to receivers in their last two games.

San Francisco 49ers tight end George Kittle (hamstring) is listed as questionable for the Week 11 divisional game on Sunday versus the Seattle Seahawks. Kittle is dealing with a little hamstring irritation and did not practice on Wednesday before putting in limited sessions on Thursday and Friday. Head coach Kyle Shanahan said he wasn't too worried about Kittle's status for this weekend, so fantasy managers should leave him in all starting lineups, even with the Niners and Seahawks kicking off in the late window on Sunday. The 31-year-old leads all tight ends in fantasy points through 10 weeks and has found the end zone seven times in his eight games this year. Oh, and he also caught five passes for 58 yards and two touchdowns in the first meeting against Seattle back on Oct. 10. Kittle will be a must-start for the rest of the year in fantasy.

San Francisco 49ers wide receiver Jauan Jennings (ankle) was added to the Week 11 injury report on Thursday after putting in a limited practice. It's a new injury for Jennings, and it could put him in danger of missing the Week 11 game against the division-rival Seattle Seahawks on Sunday. We should have a better idea of the 27-year-old's status after another practice on Friday. Jennings caught seven of 11 targets for 93 yards in the Week 10 win over the Tampa Bay Buccaneers, the second time this season he's been targeted double-digit times. Before that, he missed Weeks 7 and 8 due to injury before going on bye in Week 9. Jennings' rest-of-season value is buoyed by the fact that Brandon Aiyuk (knee) is done for the year, although he might be in danger of missing Sunday's game. If Jennings is out or limited, rookie Ricky Pearsall could be the No. 3 target behind Deebo Samuel Sr. and George Kittle (hamstring).

San Francisco 49ers running back Christian McCaffrey (Achilles) was limited for the second straight day in practice this week on Thursday. McCaffrey made his 2024 debut in the Week 10 win over the Tampa Bay Buccaneers but will most likely continue to have his workload monitored in practice the rest of the season. In his debut last Sunday, the 28-year-old All-Pro back had 19 touches for 107 scrimmage yards while playing 88 percent of the offensive snaps. We'd expect CMC to be removed from the final Week 11 injury report and be San Fran's lead back in a divisional clash against the Seattle Seahawks. Backups Jordan Mason and Isaac Guerendo had a combined two carries for five yards in McCaffrey's return. McCaffrey will be looking to build on his debut last week and is a must-start in all fantasy lineups.