San Francisco 49ers

San Francisco 49ers wide receiver Brandon Aiyuk disappointed again in a 23-17 loss to the Vikings in Minneapolis on Sunday. He finished with four receptions for 43 yards on five targets and no touchdowns. Minted with a four-year $120 million extension recently, it appears that Aiyuk is still working his way back into football shape after skipping nearly all of the 49ers preseason games and team practices. On the bright side, today was an improvement from Week 1's two-catch, 28-yard performance. As Aiyuk continues to sharpen physically and regain his rapport with quarterback Brock Purdy, it's almost certain that he'll get back to 2023 form, but it could still take another week or two. In Week 3, Aiyuk and the 49ers will head south to play the Rams in Los Angeles.

San Francisco 49ers wide receiver Deebo Samuel Sr. was impressive in a 23-17 loss to the Vikings in Minneapolis on Sunday. He caught eight of 10 targets for 110 yards receiving -- all team-high figures. Samuel Sr.'s hands were particularly sticky in this one, with multiple difficult receptions coming on contested passes. In a bit of a departure from his usual style, relatively few of his yards came after the catch. Although it didn't matter in the end, Samuel Sr. made a great hustle play in the 49ers' final possession near the goal line when linebacker Andrew Van Ginkel jumped a backward wide receiver screen pass intended for Samuel Sr., who got back to secure the ball when Van Ginkel bobbled it. Unfortunately for fantasy managers, it counted as a carry for a loss of nine yards. He would finish with two carries for minus-10 yards. Samuel Sr. will look to keep it going in a road tilt against the Los Angeles Rams next Sunday.

San Francisco 49ers running back Jordan Mason once again rewarded fantasy managers in Sunday's 23-17 loss to the Vikings in Minnesota. The second-year undrafted pro from Georgia Tech racked up exactly 100 yards and a touchdown on 20 carries and caught his only target for four yards receiving. He fumbled once, in the second quarter, but quickly recovered it. Mason once again looked the part of a Shanahan zone running back, showing vision and burst with a one-cut downhill style throughout the game. With Elijah Mitchell (hamstring) out for the season and All-Pro starter Christian McCaffrey out until at least Week 6 and possibly even longer, those who have rostered Mason have to be excited about what he's doing with the keys to the backfield. Mason will run up against the Rams in Los Angeles in Week 3 next Sunday.

San Francisco 49ers quarterback Brock Purdy fell short in Sunday's 23-17 loss to the Minnesota Vikings at U.S. Bank Stadium. Purdy finished the game having completed 28 of 36 passes for 319 yards, one touchdown, and one interception. He added two scrambles for 12 yards on the ground. Minnesota's defense kept the pressure on Purdy all afternoon, as he found himself absorbing a career-high six sacks. Purdy did make many quality throws and his lone interception came from a nice defensive deflection that may have been a simple incompletion if the ball hadn't popped upward in traffic over the middle. Purdy's other turnover happened when the ball slipped out of his hands as he threw and went directly to a waiting Jihad Ward, being ruled a fumble. Today's game represents the second disappointment in a row for fantasy owners. Next up for the 24-year-old signal-caller is a road matchup versus the Los Angeles Rams in Week 3.

San Francisco 49ers running back Christian McCaffrey (calf, Achilles) was placed on the injured reserve on Saturday. This news comes after McCaffrey was sidelined for the season opener due to Achilles tendinitis and a calf strain. He'll miss at least the next four games after being placed on the injured reserve, but he could be out longer than that. Ian Rapoport believes it could take up to six weeks for McCaffrey to heal from his Achilles tendinitis. Possibly, McCaffrey is able to play through the issue after his stint on the injured reserve, but fantasy managers should prepare for him to miss up to six weeks. In his absence, Jordan Mason figures to be the lead back and should be rostered in just about every fantasy format after his showing in Week 1.