San Francisco 49ers

San Francisco 49ers quarterback Joshua Dobbs had a fantastic fantasy performance during a 47-24 loss to the Cardinals in Arizona. The 29-year-old backup to Brock Purdy (right elbow) completed 29-of-43 attempts for a career-high 326 yards, two touchdowns, and two interceptions. He added eight carries for 17 yards, including another touchdown on a sneak. His first touchdown throw was a six-yard dart just before halftime to rookie wideout Ricky Pearsall on a slant. Later, he hit a wide-open Kyle Juszczyk down the left side for a 36-yard score. Dobbs will be a free agent this offseason and comments made to the press on Thursday about Sunday's lone start of 2024 representing an "audition not only for the team that you're on, but for the other 31 other teams" make it seem unlikely he'll be back in Northern California next year.

San Francisco 49ers wide receiver Jauan Jennings was disqualified from Sunday's meeting with the Arizona Cardinals. The wideout was having a fantastic game, amassing seven grabs (10 targets) for 52 yards before getting thrown out in the second quarter for a physical altercation with Cardinals cornerback Sean Murphy-Bunting. With the 49ers ending a disappointing season, Jennings will finish with career-highs in catches (77), targets (113), yards (975), and touchdowns (six). His stock heading into the 2025-26 campaign will already be higher than in previous years. However, if the Niners don't bring back Deebo Samuel Sr., it will increase even more.

San Francisco 49ers running back Isaac Guerendo (knee, ankle) exited during the first quarter of Sunday's Week 18 game against the Arizona Cardinals. He has been ruled out for the remainder of the contest. It was an ugly scene in Arizona as Guerendo's leg bent awkwardly while he was being tackled. He was in noticeable pain while being carted off the field, and the 49ers ruled him out with both knee and ankle injuries very quickly. He finishes Sunday's contest with two carries for five yards. All in all, he registered 420 rushing yards, 152 receiving yards, and four total touchdowns while splitting time as a depth option and starter this season. Patrick Taylor Jr. will lead the 49ers' backfield for the remainder of Sunday's contest.

San Francisco 49ers tight end George Kittle (ankle, hamstring) is officially active for Sunday's Week 18 contest against the Arizona Cardinals. He had been listed as questionable. Although the 49ers have already been eliminated from playoff contention, Kittle will be suiting up for the season finale. Quarterback Brock Purdy (elbow), however, won't play, which means Kittle will be catching passes from Joshua Dobbs. The 31-year-old ranks second among tight ends in fantasy points this season, and he enters the season finale as a high-end TE1.

San Francisco 49ers wide receiver Jacob Cowing will see an uptick in snaps this Sunday against the Arizona Cardinals in a road tilt. The rookie has been used sparingly in 2024 -- recording just two receptions and 50 yards in 11 appearances. However, he projects to see an elevated role in the offense with fellow wideout Deebo Samuel Sr. (rib, wrist) ruled inactive for the contest. Cowing has managed only 56 snaps in his debut campaign but was productive during his time at college -- breaking out in his third season with UTEP (104.2 YPG) before transferring to Arizona and notching two 85+ catch seasons. With QB Brock Purdy (elbow) set to sit, Joshua Dobbs will man the 49ers helm, so it isn't ideal for the 23-year-old wideout. Still, tight end George Kittle (ankle) is also dealing with an injury and is questionable for the matchup. Cowing could have a busy day in the team's season finale if Kittle sits. Though, he still won't be a recommended option. The former fourth-round pick comes in at RotoBaller's PPR WR87 in this week's rankings.