San Francisco 49ers

San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is limited in the team's first practice of the week on Thursday. Guerendo is dealing with two injuries and was unable to play in the Week 16 loss to the Miami Dolphins. It's good news that the 24-year-old is back on the practice field, but he might need to upgrade to a full practice in the next two days to avoid a questionable tag heading into a Monday night game against the Detroit Lions. Guerendo will operate as San Fran's lead back if he's available this week, but the problem is it might not be worth the risk leaving him in starting lineups for championship week in fantasy if he's uncertain to play on Monday night. Additionally, the matchup against Detroit's defense is not a friendly one for fantasy purposes. If Guerendo misses a second straight game, Patrick Taylor Jr. would be in line for a second straight start.

San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is expected to get back on the practice field on Thursday, according to head coach Kyle Shanahan. The rookie back is dealing with multiple injuries that kept him out of last week's game against the Miami Dolphins. His absence resulted in the 49ers using a committee approach in the backfield with two other backs sidelined as well. The hope is that Guerendo will be able to return for the Week 17 matchup against the Detroit Lions. He could be a low-end RB2 if he's healthy in time for that contest.

San Francisco 49ers rookie wide receiver Ricky Pearsall was marginally involved during a 29-17 loss to the Dolphins in Miami on Sunday. The first-round pick caught all four of his targets for 37 yards. After missing the early part of the year due to a gunshot wound, Pearsall's production escalated each game from Week 7 to Week 10, culminating in a 17.3 half-PPR performance at Tampa Bay. Any fantasy optimism quickly fizzled out though, as Pearsall then recorded three straight goose eggs. Sunday's modest performance was the most productive Pearsall has been since the aforementioned Bucs game. The 49ers will almost certainly need to make full use of their passing attack in Week 17 when the Detroit Lions bring an elite offense to Levi's Stadium, but Pearsall will be nothing more than a deep-league prayer, barring an injury ahead of him.

San Francisco 49ers tight end George Kittle delivered another solid performance during a Week 16 loss to the Dolphins in Miami on Sunday. The two-time first-team All-Pro took a co-team-leading nine targets to pace the 49ers in receptions (8) and receiving yards (106). Besides missing two games with injury, Kittle has been extremely reliable this season, surpassing half-PPR Yahoo projections in 10-of-13 starts. One would imagine that Kittle will be well-represented among fantasy teams vying for championships in Week 17 when the 49ers host the Detroit Lions. Kittle will be a no-brainer start in that one regardless of matchup but should be played with increased confidence as the Lions' prolific offense is likely to force the 49ers to make heavy use of their passing attack.

San Francisco 49ers wide receiver Deebo Samuel Sr. finally broke out of a five-game slump during a 29-17 defeat to the Dolphins in Miami on Sunday. Samuel Sr. caught seven of a co-team-high nine targets for 96 yards and a touchdown. He added five rushing attempts for 25 yards. Samuel Sr. looked angry and determined with his touches for the first time in weeks, scoring his 16-yard touchdown by running through three defenders. It's probably too little, too late for Samuel Sr.'s fantasy managers who suffered through five consecutive weeks of sub-five-point half-PPR performances, but anyone still rostering Samuel Sr. now has to at least consider him for a start in Week 17 coming off his most productive game of the season. San Francisco gets the offensive powerhouse Detroit Lions in Santa Clara on Monday night, which should force the 49ers into a pass-heavy game script, with a similar amount of carries to Sunday if rookie running back Isaac Guerendo (foot, hamstring) misses another game.