San Francisco 49ers

San Francisco 49ers tight end George Kittle (hamstring) is expected to return to practice on Wednesday after sitting out the Week 11 divisional loss to the Seattle Seahawks on Sunday due to hamstring irritation that he picked up in the Week 10 win over the Tampa Bay Buccaneers. Head coach Kyle Shanahan said Kittle was "close" to playing on Sunday. Barring a setback once the 31-year-old returns to practice this week, he should be able to return in Week 12 against the Green Bay Packers at Lambeau Field on Sunday. With elevated playing time against Seattle with Kittle out, Eric Saubert failed to take advantage and caught one pass for seven yards. Despite missing two games this year due to injury, Kittle is the TE2 in half-PPR scoring with 43 receptions, 560 yards and a league-leading seven touchdowns. If he's active in Week 12, he's a must-start in fantasy.

San Francisco 49ers rookie wide receiver Ricky Pearsall couldn't get anything going in a Week 11 home loss to the Seattle Seahawks on Sunday. The first-rounder was targeted twice but failed to bring in either pass. It's a bummer for anyone hoping Pearsall could build on his 15.3 half-PPR performance in Week 10, but shouldn't be a surprise. San Francisco's offense was never expected to support three receivers and Jauan Jennings strengthened his claim to the No. 2 -- or even No. 1 -- spot with a second-consecutive 11-target game. Pearsall is a decent stash in case Jennings runs into more injury trouble, but can't be trusted with a fantasy starting slot save for deep-league managers fishing for a touchdown. Pearsall will look to get back onto the stat sheet in Week 12 when he finds himself at Lambeau Field for a showdown with the Packers.

San Francisco 49ers wide receiver Jauan Jennings continued his ascent as a fantasy asset in a Week 11 20-17 home loss to the Seattle Seahawks on Sunday. The former seventh-round pick out of Tennessee caught 10 of 11 targets for 91 yards, including a three-yard touchdown reception to give the 49ers a short-lived lead in the fourth quarter. All four receiving numbers were team highs. Jennings isn't just filling up the stat sheet with empty yards either. He's flashing skill and grit in big spots, which all but solidifies his go-to role in the offense for the rest of the year. With two consecutive 11-target games in the books, it's going to be very hard for fantasy managers to leave Jennings out of lineups in Week 12 when the 49ers travel to Lambeau Field to take on the Packers.

San Francisco 49ers wide receiver Deebo Samuel Sr. laid down a fantasy dud in a 20-17 home loss to the Seattle Seahawks on Sunday. The South Carolina native's seven targets were the second-most on the team -- wideout Jauan Jennings had 11 for the second week in a row -- but Samuel Sr. could only total four catches for 22 yards. He got just one carry which went for a one-yard loss. Samuel Sr.'s fantasy value has rested on his big-play potential more than heavy receiving volume in recent years, but his 5.6 targets per game this season is his lowest since his rookie year in 2019. His yards per reception is still a healthy 14.8 but with only two touchdowns in nine games played, Samuel Sr. hasn't lived up to his high-end WR2 ADP. He is currently the overall WR36 in half-PPR scoring. Fantasy managers will look for Samuel Sr. to get it going next Sunday when the 49ers travel to Green Bay for a Week 12 showdown with the Packers.

San Francisco 49ers running back Christian McCaffrey disappointed again during a 20-17 loss to the Seattle Seahawks in Santa Clara on Sunday. The All-Pro out of Stanford took 19 carries for 79 yards rushing and four catches of five targets for 27 yards in the passing game. It's almost shocking to see McCaffrey fail to reach the end zone for the second consecutive game since returning from his long injury absence. McCaffrey only had three such games total last year (16 starts). It's hard to say whether McCaffrey's conditioning, opponents' defensive game-planning, or personnel changes to San Francisco's offense are to blame. The Niners' rushing attack certainly missed George Kittle (hamstring) today and his knack for springing CMC to long runs. McCaffrey's 4.2 yards per carry against a vulnerable Seattle run defense would have ranked as his fourth-lowest single-game average of 2023. At least McCaffrey appeared to stay healthy from start to finish. McCaffrey's next chance comes against the Packers at Lambeau Field in Week 12.