San Francisco 49ers

San Francisco 49ers quarterback Brock Purdy (shoulder) will play in Sunday's matchup versus the Bills. The signal-caller missed the Week 12 meeting with the Green Bay Packers. However, after practicing in full on Friday, he'll shed his questionable designation and be out there in Week 13 on Sunday night. Purdy is a capable fantasy quarterback, but with unfavorable weather conditions in Buffalo, he could have a tough time getting anything going in his return to action, meaning both teams may need to rely more on the run.

According to ESPN's Adam Schefter, San Francisco 49ers quarterback Brock Purdy (shoulder) is anticipated to play in Sunday night's matchup versus the Bills. The signal-caller wasn't on the field for the Week 12 loss to the Packers. As a result, Brandon Allen got the start, finishing with 199 yards, one touchdown, and one pick off 17-for-29 passing. If Purdy is officially cleared to suit up on Sunday, he could have a tough time getting it going, considering heavy snow is in the forecast for Buffalo. Still, he should at least be considered a starting fantasy option in multi-QB setups. But if Purdy isn't out there, Allen doesn't have much upside in any format.

San Francisco 49ers kicker Jake Moody is in Buffalo for a Week 13 matchup against the Bills. Since missing three field goals in his first game back from a multi-week ankle injury, Moody has been perfect, hitting two-of-two field goal attempts and all three extra-point tries. When confidence is high in San Francisco's offense, Moody is almost as good a fantasy choice as any, but this isn't one of those times. Buffalo's defense is decent, but the real problem is the state of the Niners' offense. Although quarterback Brock Purdy (shoulder) is expected to play, San Francisco's offensive line will be missing All-Pro left tackle Trent Williams and starting left guard Aaron Banks (concussion). Offensive weapons Christian McCaffrey and Deebo Samuel Sr. have been slumping and a cold, loud, possibly snowy Highmark Stadium isn't exactly the best get-right situation for the Niners -- or for Moody's accuracy for that matter. In most leagues, fantasy managers can do better than Moody in Week 13, doubly true if Purdy were held out again.

If the San Francisco 49ers plan to knock off the Buffalo Bills in Orchard Park on Sunday night, the team will likely need tight end George Kittle to continue his run of production. In each game he's played since a disappointing Week 1, Kittle has outperformed half-PPR projections, culminating in last week's six-target, six reception, 90-yard, one-touchdown game in Green Bay. After spending all of 2023 as the epitome of a boom/bust fantasy asset, this season Kittle has flipped the script and become the 49ers' steadiest offensive producer. The Bills are the 13th-best in the league at limiting fantasy tight end half-PPR points per game. With starting quarterback Brock Purdy (shoulder) on the good side of questionable, San Francisco's offense still has an uphill battle as they'll be missing All-Pro left tackle Trent Williams (ankle) for the second-straight game and left guard Aaron Banks (concussion). A loud, cold, and maybe snowy environment will also make things tougher offensively. Kittle should considered a mid-high TE1 in Week 13, and a must-start even if Purdy can't go.

San Francisco 49ers wide receiver Deebo Samuel Sr. will attempt to break out of a four-game touchdown-less slump when the team goes to Buffalo to face the Bills in Week 13. The sixth-year pro's performance in Green Bay last week was ugly. Samuel Sr. was targeted four times by backup quarterback Brandon Allen, catching only one pass for 21 yards. Two of those unfulfilled targets should have been caught. He had no rushing attempts. Amid speculation that Samuel Sr. is looking a little "thicker" lately, his most explosive play in recent memory was an 87-yard kick return at Lambeau called back for holding. It could be rough-going again in a loud, cold, and maybe snowy Orchard Park, as the Bills have allowed the eighth-fewest half-PPR points to opposing wide receivers. Significantly, San Francisco's offensive line is banged up, with All-Pro left tackle Trent Williams (ankle) set to miss a second-straight game and starting left guard Aaron Banks (concussion) also out. Still, Samuel Sr. likely offers at least a modest rebound from last week with starting quarterback Brock Purdy (shoulder) expected to play. Samuel Sr. is a WR3/FLEX this week, with a downgrade to WR4 if Purdy can't go.