San Francisco 49ers

San Francisco 49ers running back Christian McCaffrey (knee) is dealing with a PCL injury after getting hurt in the Sunday night loss to the Buffalo Bills and is facing a six-week recovery, according to head coach Kyle Shanahan. McCaffrey was officially placed on Injured Reserve on Monday, and he will miss at least the rest of the regular season. The Niners have work to do just to get into the postseason, so we've most likely seen the last of CMC in 2024. In addition to McCaffrey, Jordan Mason (ankle) suffered a high-ankle sprain on Sunday night and will miss at least the next four games. It means that rookie Isaac Guerendo should become San Fran's top back moving forward, making him a priority waiver-wire addition this week. It was a disastrous 2024 campaign for the 28-year-old McCaffrey after winning Offensive Player of the Year in 2023. He finishes with 50 carries for 202 yards and no TDs in four games.

San Francisco 49ers tight end George Kittle nearly ghosted fantasy managers in a 35-10 loss to the Bills in a snowy Orchard Park on Sunday night. The leader in half-PPR points per game at tight end had his worst game of the season, finishing with one reception on two targets for seven yards. Kittle's feeble output probably has little to do with Kittle himself, as the entire 49ers offense was behind the eight-ball from the start. The snow, the offensive line injuries, and running back Christian McCaffrey leaving early were never likely to lead to great offensive numbers for any 49ers. There is not a lot to be done from a fantasy perspective besides flush this one. Kittle will get the Chicago Bears in a neutral matchup at home in Week 14, where he'll once again be a must-start.

San Francisco 49ers wide receiver Deebo Samuel Sr. didn't do much to regain fantasy managers' confidence during a 35-10 defeat to the Bills in Buffalo on Sunday night. Samuel Sr. finished with four receptions on five targets for 20 yards receiving. He also lost a fumble. The modest reception total represented a team-high, and the targets tied fellow wideout Jauan Jennings for the team lead. In fairness to Deebo, San Francisco's entire offense was discombobulated in the snowy affair. Down two offensive linemen in heavy snow before losing running back Christian McCaffrey to a knee injury makes for a rough assignment against one of the best teams in football. At the same time, it marks the third straight game that Samuel Sr. has been held below five half-PPR points in fantasy. It's worth noting that Samuel Sr.'s lone unfulfilled target on Sunday should have been caught, which followed two crucial drops in Green Bay last week. Samuel Sr. gets another chance to turn it around against the Chicago Bears at home in Week 14.

San Francisco 49ers wide receiver Jauan Jennings had a muted performance in a 35-10 loss to the Bills in Buffalo on Sunday night. The former seventh-round pick caught three of five targets for a team-high 56 yards. San Francisco's passing offense was almost nonexistent in the snowy affair, as Jennings shared the target lead with Deebo Samuel Sr. There should be sunnier days ahead for Jennings, who is the half-PPR WR23 in points per game this year, sandwiched between Tennesee's Nick Westbook-Ikhine and Jaguars rookie wideout Brian Thomas Jr. Jennings has two favorable matchups left on tap this season -- both at home -- in Week 15 versus the Rams and Week 17 versus Detroit. Next week, however, he gets the Chicago Bears who have allowed the sixth-fewest points per game to wide receivers.

San Francisco 49ers running back Jordan Mason found some traction in an ugly 35-10 loss to the Bills in Orchard Park on Sunday night. The 25-year-old did most of his work after starter Christian McCaffrey (knee) left the game, finishing with 78 yards on 13 carries and no touchdowns. In a development that is sure to shake up fantasy leagues everywhere, McCaffrey's injury is feared to be significant, opening up championship hopes to those who held on to Mason through CMC's return. In six starts this year, Mason averaged 5.1 yards per carry and scored three touchdowns. Ahead of Week 14, fantasy managers in leagues where Mason is unclaimed should be prepared to break the bank on the waiver wire if McCaffrey is done for the year. Mason and the 49ers get the Chicago Bears at home next week, in a must-win against a vulnerable rush defense.