San Francisco 49ers

According to Nick Wagoner of ESPN, San Francisco 49ers wide receiver Deebo Samuel Sr. (rib/knee) did not practice on Wednesday. Samuel saw his typical snap count during Monday's loss to the Detroit Lions. Fantasy managers should continue to keep a close eye on his status throughout the week, as he may be in danger of missing Sunday's game against the Arizona Cardinals. Samuel has found the end zone in each of his past two games but has had an overall disappointing season. Since Week 10, he has just averaged a mere 9.0 PPR points per game. During this span he has seen just 5.3 targets per game. If Samuel is unable to play on Sunday, Jauan Jennings will operate as the top wideout in the offense and rookie wide receiver Ricky Pearsall would slot in as the No.2 option.

According to Nick Wagoner of ESPN, San Francisco 49ers tight end George Kittle (ankle/hamstring) did not practice on Wednesday. Fantasy managers should continue to monitor his status leading up to their final game of the season against the Arizona Cardinals. With the 49ers out of playoff contention, Kittle may face an uphill battle to clear protocol in order to suit up. On Monday evening, during their loss to the Detroit Lions, Kittle brought in all eight of his targets for 112 yards. This was his second-straight contest tallying at least 100 yards and the fourth time this season he has accomplished this feat. Since Week 12, he has averaged a strong 15.2 PPR points per game. Even though Joshua Dobbs will be under center on Sunday, Kittle remains a must-start tight end if he is cleared to play.

According to Adam Schefter of ESPN, San Francisco 49ers quarterback Joshua Dobbs will get the starting nod against the Arizona Cardinals this weekend. Dobbs came in for relief late in Monday's game when Brock Purdy (elbow) sustained an injury. The team is opting to lean on the side of caution with Purdy and will let their backup QB start under center in their final game. On his lone drive on Monday night, Dobbs tallied a seven-yard rushing score with 35 passing yards. When Purdy missed time earlier this season, Brandon Allen got the start, but now the coaching staff will turn to Dobbs. Dobbs is worth a look as QB2 in all formats, as he does carry some rushing upside in this matchup despite facing a tougher Arizona defense that has allowed the seventh-fewest PPR points to opposing QBs.

San Francisco 49ers kicker Jake Moody will assume his placekicking duties in the Week 18 season-finale against the Arizona Cardinals, according to David Lombardi of The Athletic. The 25-year-old has struggled since returning from the Injured Reserve list and missed three of his seven kicks in Week 17's loss to the Detroit Lions. Moody has not lived up to his third-round price in the 2023 NFL Draft, so the organization could add kicking competition heading into next season. However, he'll keep his job for at least one more week. It's tough to trust him in DFS or fantasy football based on his recent struggles.

San Francisco 49ers quarterback Brock Purdy (elbow) suffered a right-elbow contusion in the Monday Night Football loss to the Detroit Lions. The 2022 seventh-round pick is unlikely to play in the team's season finale against the Arizona Cardinals, but no long-term issues are expected. Purdy regressed this season after a fantastic 2023 campaign, throwing for 3,864 yards, 20 touchdowns, and 12 interceptions en route to the 49ers missing the playoffs for the first time since 2020. After Purdy exited the Week 17 game, backup Joshua Dobbs completed three of his four passing attempts for 35 yards and rushed for a seven-yard touchdown. He'll likely draw the start in the Week 18 finale and could have fantasy or DFS upside if key 49ers' pass-catchers are active.