San Francisco 49ers

San Francisco 49ers wide receiver Jauan Jennings had a muted performance during a 38-10 loss to the Packers in Green Bay on Sunday. The 6-foot-3 former seventh-rounder caught five of seven targets for 40 yards. Except for tight end George Kittle, San Francisco's entire offense struggled to put up numbers during a game in which they were fighting through the absence of quarterback Brock Purdy (shoulder) and left tackle Trent Williams (ankle). On the bright side, Jennings' target total led all 49ers and he continues to out-produce both Deebo Samuel Sr. and rookie Ricky Pearsall. However, there is no guarantee that the 49ers will be any healthier when they play the Bills in Week 13. Jennings managers will need to monitor the status of Purdy -- and to a lesser degree, Williams -- before setting expectations for the emergent wideout in Buffalo on Sunday Night Football.

San Francisco 49ers wide receiver Deebo Samuel Sr. came into a Week 12 matchup at the Green Bay Packers in a modest slump, averaging 8.3 half-PPR points over his past three games. The former Gamecock's struggles bottomed out on Sunday, as he finished with one catch on four targets for 21 yards. Much of San Francisco's offensive ineptitude on the day can be explained by starting quarterback Brock Purdy (shoulder) and left tackle Trent Williams (ankle) watching from the sidelines. However, outside of his one catch-and-run and 87-yard kick return nullified by a holding call, Samuel Sr. was part of the problem. With two crucial drops, including one that directly led to a Brandon Allen interception, it's hard to say with a straight face that Samuel Sr.'s fantasy day was a victim of circumstance. In Week 13, things don't get any easier for Samuel Sr. and the Niners as they travel to Buffalo to face the Bills. If San Francisco's injury problems at quarterback and offensive line linger, Samuel Sr. will be hard to trust in fantasy lineups.

San Francisco 49ers running back Christian McCaffrey continued his post-injury slump in a 39-10 loss to the Green Bay Packers at Lambeau Field on Sunday. Last year's overall RB1 finished with 31 yards and a lost fumble on 11 carries while adding three catches of four targets for 37 yards. The last time a healthy McCaffrey scored so few half-PPR points in a game was way back in Week 2 of 2019 with the Carolina Panthers. Opinions may vary on how much blame to pin on McCaffrey himself -- it's fair to question his football shape after his lengthy absence -- but other circumstances are certainly in play. With career backup Brandon Allen filling in for quarterback Brock Purdy (shoulder), Green Bay was likely emboldened to key in on the running game. All-Pro left tackle Trent Williams (ankle), who is just as important to the Niners' rushing attack as its passing game, was also out. If Purdy and Williams can return in Week 13 at Buffalo, it's safe to flush and forget this one for the most part. But if not, McCaffrey will be at risk for continued struggles.

San Francisco 49ers quarterback Brandon Allen didn't have much to work with during a 38-10 loss to the Packers in Green Bay on Sunday. Filling in for starter Brock Purdy (shoulder), the sixth-year career backup went 17-of-29 for 199 yards, one touchdown, and one interception. Allen was behind the eight ball from the beginning, getting his first start since the 2021 season on the road against a quality defense with future Hall of Fame left tackle Trent Williams (ankle) out. Allen wasn't perfect but made some quality throws, including the three-yard touchdown to tight end George Kittle. San Francisco's receivers didn't do Allen many favors, most notably Deebo Samuel Sr., who conspicuously dropped two passes, including the one that directly caused Allen's only interception. A number of drive-stalling offensive penalties and San Francisco's inability to win in the trenches on run plays didn't help, either. Purdy's status for Week 13 at Buffalo is still up in the air, so Allen could be in line for another start, but won't be recommended in standard leagues.

San Francisco 49ers quarterback Brock Purdy (shoulder) has been ruled out for Week 12, but the team believes he'll be able to play next weekend against the Buffalo Bills. Purdy's progress was inconsistent earlier this week, and the team did think he'd be able to suit up against the Green Bay Packers before ruling him out. Fantasy managers should expect all Niners playmakers to take a step back in terms of fantasy production. Meanwhile, interim starter Brandon Alle will rank as a low-end QB2.