Isaac Guerendo's Stats, Metrics, Game Logs, Projections & Rankings

San Francisco 49ers running back Isaac Guerendo will handle kickoff returns in place of injured wide receiver Deebo Samuel Sr. (calf) in Week 3, according to Matt Barrows of The Athletic. Barrows notes that the majority of kickoffs in 2024 have resulted in touchbacks, but if the Rams attempt any kicks that are returnable, Guerendo will handle that duty. The 24-year-old rookie has seen minimal opportunities on offense this year, rushing just once while handling one percent of offensive snaps in Week 2. He's off the fantasy radar.

San Francisco 49ers running back Isaac Guerendo (groin) will suit up for Monday's game against the New York Jets. The rookie back missed over a week of practice due to a groin issue, but was able to get in a few limited practice sessions. Guerendo practiced in full on Saturday and has no injury designation ahead of Week 1. Lead back Christian McCaffrey (calf, Achilles) is listed as questionable ahead of Monday's game. Guerendo would likely see a significant workload if McCaffrey sits out which seems unlikely. That being said, Guerendo could see a few touches as the third string back. He looks more like a stash for fantasy managers in dynasty or deep leagues.

San Francisco 49ers running backs Elijah Mitchell (hamstring), Isaac Guerendo (hamstring) and Patrick Taylor Jr. (undisclosed) have all returned to training camp practices in the last two days. The only Niners running back out of practice still is starter Christian McCaffrey (calf), but he's been doing heavy work on the side. Mitchell will now try to hold off Jordan Mason for the RB2 role in San Fran. Although McCaffrey will end up missing the entire preseason, the 49ers aren't worried that he'll miss the start of the regular season. The 26-year-old former sixth-rounder in 2021 out of Louisiana would become a weekly fantasy option if CMC were to miss extended time, but Mitchell has battled injury issues of his own in his three years in the NFL and has played in a total of 27 games (12 starts) since entering the league. Guerendo is behind in his development heading into his rookie year, but he, too, could be a threat to Mitchell's spot on the depth chart eventually in 2024.

San Francisco 49ers head coach Kyle Shanahan said on Sunday night that he's "hoping" that rookie running back Isaac Guerendo (hamstring) will return to training camp practice this week and get some snaps in Friday's preseason finale against the Las Vegas Raiders on the road. Guerendo could easily be looking at a redshirt rookie season in the NFL after initially injuring his hamstring at the start of training camp on July 24. The 24-year-old fourth-rounder has missed three-plus weeks of valuable reps in camp, including both of the team's preseason games to this point. Saying San Fran's backfield has been beat up this summer would be an understatement, as Christian McCaffrey (calf), Elijah Mitchell (hamstring) and Jordan Mason (hip) also have injury designations. When healthy, the speedy Guerendo figures to be the Niners' RB3, but he's behind the eight ball developmentally already and can be avoided in standard 12-team fantasy drafts.

San Francisco 49ers running back Isaac Guerendo (hamstring) is dealing with a significant hamstring strain and will be out for a few weeks, according to head coach Kyle Shanahan. It's a tough development for the fourth-round rookie from Louisville, who will miss valuable reps as he looks to compete for the RB2 job behind Christian McCaffrey. Guerendo was widely unknown heading into the pre-draft process, but his 4.33 40-yard dash time at the NFL Combine raised eyebrows and got him selected at the start of Day 3 of the 2024 NFL Draft. While his injury could slow down his development and chances to make an impact early in his career, he remains an intriguing late-round flier in deep fantasy football leagues.