Isaac Guerendo's Stats, Metrics, Game Logs, Projections & Rankings

San Francisco 49ers head coach Kyle Shanahan said on Sunday night that he's "hoping" that rookie running back Isaac Guerendo (hamstring) will return to training camp practice this week and get some snaps in Friday's preseason finale against the Las Vegas Raiders on the road. Guerendo could easily be looking at a redshirt rookie season in the NFL after initially injuring his hamstring at the start of training camp on July 24. The 24-year-old fourth-rounder has missed three-plus weeks of valuable reps in camp, including both of the team's preseason games to this point. Saying San Fran's backfield has been beat up this summer would be an understatement, as Christian McCaffrey (calf), Elijah Mitchell (hamstring) and Jordan Mason (hip) also have injury designations. When healthy, the speedy Guerendo figures to be the Niners' RB3, but he's behind the eight ball developmentally already and can be avoided in standard 12-team fantasy drafts.

San Francisco 49ers running back Isaac Guerendo (hamstring) is dealing with a significant hamstring strain and will be out for a few weeks, according to head coach Kyle Shanahan. It's a tough development for the fourth-round rookie from Louisville, who will miss valuable reps as he looks to compete for the RB2 job behind Christian McCaffrey. Guerendo was widely unknown heading into the pre-draft process, but his 4.33 40-yard dash time at the NFL Combine raised eyebrows and got him selected at the start of Day 3 of the 2024 NFL Draft. While his injury could slow down his development and chances to make an impact early in his career, he remains an intriguing late-round flier in deep fantasy football leagues.

San Francisco 49ers running back Isaac Guerendo (hamstring) suffered a hamstring injury at practice Wednesday, significant enough to be visibly upset by it. Guerendo was pick 129 in the fourth round of the 2024 NFL draft by the 49ers, hoping to impact one of the league's best-rushing offenses. The San Francisco 49ers' rushing offense revolves heavily around Christian McCaffrey, who recorded 272 carries in 16 games during the 2023 season, tied for the second-most in the NFL. If McCaffrey were injured, another player would have a significant opportunity to step into the starting running back role. Should Guerendo miss time due to injury, Elijah Mitchell becomes the clear backup and handcuff to McCaffrey, with Jordan Mason likely to regain the third-string role. Guerendo should be off of fantasy radars if injured, but the backup role in San Francisco is one to keep track of all season.