Isaac Guerendo's Stats, Metrics, Game Logs, Projections & Rankings

San Francisco 49ers running back Isaac Guerendo is set to make his first career start on Sunday against the Chicago Bears. The Louisville product was expected to be the team's RB4 to start the year, but a preseason injury knocked Elijah Mitchell (hamstring) out for the year. Now, Christian McCaffrey (knee) and Jordan Mason (ankle) are on Injured Reserve. This leaves Guerendo in the RB1 role in Kyle Shanahan's offense, a valuable role for fantasy football. "I think he is ready to go," Shanahan said. "He only got better and he's gotten better throughout the year. So, I think he's ready for this." The 24-year-old has rushed 42 times for 246 yards and two touchdowns this season in his breather-back role, and he's in a potential smash spot against Chicago, a team that has allowed the 10th-most fantasy points per game to ball carriers. He is a virtual must-start back in Week 14, especially with six teams on a bye.

With both San Francisco 49ers running backs Christian McCaffrey (knee) and Jordan Mason (ankle) landing on Injured Reserve on Monday, rookie Isaac Guerendo is now in line for lead-back duties heading into a Week 14 matchup against the visiting Chicago Bears this Sunday. McCaffrey and Mason won't be eligible to return until the Week 18 regular-season finale against the division-rival Arizona Cardinals, so they are effectively off the fantasy radar for the rest of the way in single-year leagues with championship matchups typically coming in Week 17. The 24-year-old Guerendo has a healthy 5.9 yards per carry on his 42 rushing attempts in his first year in the NFL while adding five receptions for 19 yards. Fantasy managers may not want to expect him to be that efficient moving forward in a lead-back role, but he should at least have weekly RB2 upside with a huge volume increase.

San Francisco 49ers rookie running back Isaac Guerendo took over for Jordan Mason (shoulder) and performed well in a 30-24 Week 8 home victory over the Dallas Cowboys on Sunday night. After Mason left in the first half, Guerendo took almost all of the backfield carries, finishing with 14 carries for 85 yards and a touchdown. The performance solidified Guerendo as a viable fantasy starter when given the chance. In two games this year with Christian McCaffrey (Achilles) and Mason out, Guerendo has taken 24 carries for 184 yards and a touchdown with minimal backfield competition from the fourth-string Patrick Taylor Jr. However, Guerendo's fantasy value as a handcuff is likely to crash on the other side of a Week 9 bye as both Mason and McCaffrey could return for a Week 10 trip to Tampa Bay. For as good as Guerendo has looked, San Francisco's rushing game has strictly supported one running back in fantasy dating back to 2023.

San Francisco 49ers rookie running back Isaac Guerendo will return to a backup role when the team hosts the Kansas City Chiefs on Sunday. Last week during a win in Seattle, when starter Jordan Mason (shoulder) left the game during the second quarter, Guerendo filled in nicely with 10 carries for 99 yards, including a 76-yard run to put the game away for San Francisco. However, with Mason off the injury report after logging a full practice on Friday, Guerendo will probably be relegated to the one-to-five carries that he's logged this season when Mason has been healthy. The 6-foot, 221-pound fourth-rounder is a worthwhile stash while Christian McCaffrey (Achilles/calf) is out in case Mason gets hurt again, but he is not a viable starter in Week 7.

San Francisco 49ers rookie running back Isaac Guerendo filled in nicely for starter Jordan Mason (shoulder) in a Week 6 36-24 victory versus the Seattle Seahawks at Lumen Field. Mason left the game with an apparent shoulder injury in the second quarter and came back in for one carry just after the half, never to return. Guerendo did most of the replacement work, finishing with 10 carries for 99 yards. He was not targeted in the passing game. Though Guerendo looked competent overall, it's worth noting that the bulk of his yardage came on a fourth-quarter 76-yard run that salted the game away for San Francisco. He may have scored on the play but appeared to pull up at the last second to allow the 49ers to work more clock. Guerendo will be a top waiver target heading into Week 7 against Kansas City if Mason is sidelined, but it's worth noting that fourth-year back Patrick Taylor Jr. was involved as well, with five carries and a target of his own in Mason's absence.