Buffalo Bills

Buffalo Bills wide receiver Curtis Samuel (toe) remained a limited participant in Friday's practice. Samuel was limited during Thursday's initial session with a toe injury. Fantasy managers should continue to monitor his status during Saturday's practice as it should provide clarity on his availability for Monday's game. However, seeing him participate in a limited capacity earlier in the week is a promising sign that he might be able to suit up. No.1 wide receiver Khalil Shakir (ankle) and No.1 running back James Cook (toe) have not participated in a practice session this week which could open the door for Samuel to see more opportunities. If Samuel sees an increase in playing time due to the other injuries, he could be worth a look as a flex option in deeper formats on Monday evening.

Cleveland Browns wide receiver Amari Cooper has struggled with drops and a lack of production for the majority of the 2024 season, going over 35 receiving yards just twice in five games. He will look to shake off his slow start in a road matchup against the Philadelphia Eagles in Week 6. Cooper did not practice on Wednesday but it was just a veteran rest day and was not injury related. The Eagles have been very generous to opposing wideouts this season, allowing the most fantasy points per game to the position through four games. It remains to be seen whether Cooper and a struggling Deshaun Watson will be able to capitalize on this plus matchup, however, as they disappointed last week against a Washington Commanders secondary that is allowing the second-most fantasy points per game. Cooper is on the radar as a WR3 in fantasy but he will be hard to trust as much more than that despite the excellent matchup.

Buffalo Bills wide receiver Khalil Shakir (ankle) didn't suit up for Friday's practice, which is now the third straight day that he has sat out. Shakir is in danger of missing his second straight game, but still has a chance to practice on Saturday. Head coach Sean McDermott recently said that Shakir is day-to-day, so fantasy managers shouldn't be too worried about it. If Shakir sits, Keon Coleman would move into the No. 1 wideout role. The rookie wideout finished with one reception on five targets for 49 yards and a touchdown last week without Shakir. He figures to once again have a bigger role if Shakir is unable to play.

Buffalo Bills running back James Cook (foot, toe) was unable to suit up for Friday's practice session. Cook hasn't been able to practice all week, which puts him on the wrong side of questionable ahead of the Week 6 matchup against the New York Jets. It's worth noting that the Bills do play on Monday, so Cook will get another chance to practice on Saturday. If he sits, Ty Johnson and Ray Davis would likely split up the workload in the backfield. Neither of them have done much of anything on the field this season. Davis has rushed 26 times for 75 yards, which is 2.9 yards per carry. Fantasy managers should consider Davis a shaky RB3 if Cook sits out.

Buffalo Bills wide receiver Curtis Samuel (foot/toe) was limited in Thursday's practice. Despite being limited, he was back on the field after missing Wednesday's practice. Samuel has been dealing with a foot/toe injury from a turf toe issue that has lingered since the preseason. This adds to a Bills injury report already crowded at the wide receiver position, with Khalil Shakir (ankle) and Mack Hollins (shoulder) also dealing with injuries. Samuel will have a few more chances to log a full practice to avoid an injury designation ahead of Monday's matchup with the New York Jets. The 28-year-old caught just one pass for zero yards in last week's loss to the Texans, despite his increased playing time. Samuel has been a non-factor in fantasy so far and is a dart throw (ranked WR70 at RotoBaller) at best in a tough matchup against the Jets in Week 6.